故事講述兩個在當代具有超自然能力的人“喬治”和“米歇爾”。在當地一個不知名的醫院里做苦工，他們生活絕望-因為米歇爾是吸血鬼，喬治是狼人。他們決定改過自新，住在了一起才發現，一個女鬼(Annie)死于神秘的情況并且經常鬧鬼。在這個一個對兩個人的競賽中(Threesome 有三人一組或者一人對抗兩人的意思，這里應該指安妮女鬼和喬治米歇爾搭檔)，他們與超自然生物對抗，希望通過這樣的生活方式與他們的鄰居-人類相處。
　　Contemporary Supernatural Drama About George And Mitchell, A Pair Of Perennial Outsiders. Working In The Anonymous Drudgery Of The Local Hospital, They Live Lives Of Quiet Desperation - Because Mitchell Is A Vampire And George Is A Werewolf. Deciding To Turn Over A New Leaf, They Move Into A House Together, Only To Find That It Is Haunted By Annie, The Ghost Of A Woman Killed In Mysterious Circumstances. As A Threesome, They Deal With The Challenges Of Being Supernatural Creatures, Bonded By Their Desire To Adopt The Lifestyle Of Their Neighbours - Humanity.